Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture.
Werner syndrome (WS) is a premature aging disorder characterized by chromosomal instability and cancer predisposition.Mutations in WRN are responsible for the Dust Pans disease and cause telomere dysfunction, resulting in accelerated aging.Recent studies have revealed that cells from WS patients can be successfully reprogrammed into induced pluripo